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A substrate for the trypsin-like activity of the 20S proteasome.
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Product Details
| Alternative Name |
Bz-VGR-AMC |
|---|---|
| Appearance |
White powder. |
| CAS |
87779-49-5 |
| Formula |
C30H37N7O6 . TFA |
| MW |
591.67 |
| Purity |
≥98% (HPLC) |
| Sequence |
Bz-VGR-AMC, Fluorogenic Substrate |
| Solubility |
Soluble in methanol or DMSO. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats: T. McFadden, et al.; Nutr. Neurosci. 13, 1 (2022), Abstract
- Comprehensive Analysis of Proteasomal Complexes in Mouse Brain Regions Detects ENO2 as a Potential Partner of the Proteasome in the Striatum: N. Esfahanian, et al.; Cell. Mol. Neurobiol. , (2021), Abstract
- Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity: McFadden, T., Musaus, M., et al.; Behav. Brain Res. 393, 112787 (2020), Reactant(s): Rat, Abstract
- Mitochondrial Protein Poldip2 (Polymerase Delta Interacting Protein 2) Controls Vascular Smooth Muscle Differentiated Phenotype by O-Linked GlcNAc (N-Acetylglucosamine) Transferase-Dependent Inhibition of a Ubiquitin Proteasome System: Paredes, F., Williams, H. C., et al.; Circ. Res. 126, 41 (2020), Abstract
- Skeletal Muscle Denervation Investigations: Selecting an Experimental Control Wisely: H. Liu, et al.; Am. J. Physiol. Cell Physiol. 316, C456 (2019), Abstract
- Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience 418, 1 (2019), Abstract
- Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers: H.M. Ni, et al.; Am. J. Pathol. 189, 1363 (2019), Abstract
- Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer’s Disease Model: N.K. Lee, et al.; Sci. Rep. 7, 39340 (2017), Abstract — Full Text
- Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases: L. Lauinger, et al.; Nat. Chem. Biol. 13, 709 (2017), Abstract — Full Text
- Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener. 11, 52 (2016), Application(s): Proteasome activity, brain homogenate, Abstract — Full Text
- Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome: H.M. Lee, et al.; PLoS One 11, e0166831 (2016), Abstract — Full Text
- Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome, Abstract — Full Text
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