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Butyrolactone I

BML-CC210

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CDK inhibitor

Cell permeable and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. G1/S and G2/M transitions, in W138 cells, were inhibited, concurrent with inhibition of the phosphorylations of, respectively, retinoblastoma protein and histone H1. It is an important tool for probing the cellular roles of CDKs. Blocks Fas-induced apoptosis. Displays antitumor activity.

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Product Details

Appearance	White solid.
CAS	87414-49-1
Couple Target	CDK
Couple Type	Inhibitor
Formula	C₂₄H₂₄O₇
MW	424.5
Purity	≥99% (TLC)
Solubility	Soluble in 100% ethanol (25mg/ml) or DMSO(>10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Changing the Inoculum Type From Preculture to Spore Suspension Markedly Alters the Production of Secondary Metabolites in Filamentous Microbial Coculture: T. Boruta, et al.; Curr. Microbiol. 82, 31 (2023), Abstract
Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes: A.M. Petrov, et al.; Brain Commun. 2, fcaa043 (2020), Abstract — Full Text
Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures: T. Boruta, et al.; Appl. Microbiol. Biotechnol. 100, 3009 (2016), Application(s): Cell culture, Abstract — Full Text
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1): T. Shiromizu, et al.; Genes Cells 11, 477 (2006), Abstract
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis: H. Lin, et al.; J. Biol. Chem. 279, 29302 (2004), Abstract — Full Text
Butyrolactone I reversibly inhibits meiotic maturation of bovine oocytes, without influencing chromosome condensation activity: M. Kubelka, et al.; Biol. Reprod. 62, 292 (2000), Abstract — Full Text
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia: N. Sankrithi and A. Eskin; J. Neurochem. 72, 605 (1999), Abstract
Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines: M. Suzuki, et al.; Cancer Lett. 138, 121 (1999), Abstract
An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells: M. Wada, et al.; Anticancer Res. 18, 2559 (1998), Abstract
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines: K. Nishio, et al.; Anticancer Res. 16, 3387 (1996), Abstract

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Butyrolactone I

BML-CC210

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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