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Bupropion . HCl

BML-NS111

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Inhibitor of dopamine and norepinephrine transporters

Inhibits dopamine and norepinephrine transporters (K_i=2.8 and 1.4µM respectively). Inhibits the serotonin transporter at higher concentration (K_i=45µM). In clinical use as an antidepressant and for smoking cessation. Also acts as a nicotinic receptor antagonist.

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Product Details

Appearance	White solid.
CAS	31677-93-7
Couple Target	Dopamine transporter, Norepinephrine transporter
Couple Type	Inhibitor
Formula	C₁₃H₁₈ClNO . HCl
MW	276.2
Purity	≥98% (HPLC)
Solubility	Soluble in water (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats: S.L. Faison, et al.; BMC Pharmacol. Toxicol. 17, 49 (2016), Abstract
Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies: G.I. Papakostas, et al.; J. Clin. Psychiatry 69, 1287 (2008), Abstract
Treating tobacco dependence: state of the science and new directions: C. Lerman, et al.; J. Clin. Oncol. 23, 311 (2005), Abstract
Bupropion is a nicotinic antagonist: J.E. Slemmer, et al.; J. Pharmacol. Exp. Ther. 295, 321 (2000), Abstract — Full Text
Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo: B.R. Cooper, et al.; J. Pharmacol. Exp. Ther. 215, 127 (1980), Abstract

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Bupropion . HCl

BML-NS111

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