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Bupivacaine

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Na⁺ channel blocker

Sodium channel blocker. Clinically useful local anesthetic.

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Alternative Name	Bupivacaine hydrochloride monohydrate
Appearance	White crystalline powder.
CAS	73360-54-0
Couple Target	Sodium channel
Couple Type	Blocker
Formula	C₁₈H₂₈N₂O . HCl . H₂O
MW	342.9
Purity	≥98% (UHPLC)
Solubility	Soluble in water (5mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Bupivacaine and ropivacaine: comparative effects on nerve conduction block: H. Bariskaner, et al.; Methods Find. Exp. Clin. Pharmacol. 29, 337 (2007), Abstract
Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cord: A. Olschewski, et al.; Anesthesiology 88, 172 (1998), Abstract
An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum: D. Leonoudakis, et al.; J. Neurosci. 18, 868 (1998), Abstract — Full Text

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