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Bumetanide

BML-EI168

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Na⁺ channel blocker

Bumetanide is a specific inhibitor of Na-K-2Cl cotransport. It binds specifically, saturably and with high affinity to membranes from a large variety of cells. A clinically useful diuretic.

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Product Details

Appearance	White solid.
CAS	28395-03-1
Couple Target	Sodium channel
Couple Type	Blocker
Formula	C₁₇H₂₀N₂O₅S
MW	364.4
Purity	≥98%
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly: R. Oberbauer, et al.; Clin. Pharmacol. Ther. 57, 42 (1995), Abstract
Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells: J.D. Klein & W.C. O’Neill; J. Biol. Chem. 265, 22238 (1990), Abstract
The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid: E.B. Pewitt, et al.; J. Biol. Chem. 265, 20747 (1990), Abstract
Characteristics and functions of Na-K-Cl cotransport in epithelial tissues: S.M. O’Grady, et al.; Am. J. Physiol. 253, C177 (1987), Abstract

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Bumetanide

BML-EI168

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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