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Bufotalin

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Na⁺/K⁺ ATPase inhibitor

Less potent Na⁺/K⁺-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.

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Alternative Name	(3β,5β,16β)-16-(Acetyloxy)-3-,14-dihydroxybufa-20,22-dienolide, 3β,14,16β-Trihydroxy-5β bufa-20,22-dienolide 16-acetate
Appearance	White to off-white solid.
CAS	471-95-4
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₆H₃₆O₆
MI	14: 1477
MW	444.6
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol or chloroform.
Source	Isolated from Bufonis venom.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 119 (2001), Abstract
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1999), (Review), Abstract

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