Bufalin

BML-AP303

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ATPase inhibitor

Cardiotonic steroid specific Na⁺/K⁺-ATPase inhibitor. More potent than ouabain (Prod. No. BML-CM109). Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein.

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Product Details

Alternative Name	(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide, 5β,20(22)-Bufadienolide-3β,14-diol
Appearance	White to off-white solid.
CAS	465-21-4
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₂₄H₃₄O₄
MI	14: 1471
MW	386.5
Purity	≥97% (HPLC)
RTECS	EI2962500
Solubility	Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml, warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells: Burkard, C., Verheije, M. H., et al.; J. Virol. 89, 4434 (2015), Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005), Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004), Abstract
The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 19 (2001), Abstract
Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells: N. Kawazoe, et al.; Oncogene 18, 2413 (1999), Abstract
Na+, K+-ATPase inhibitors down-regulate gene expression of the intracellular signaling protein 14-3-3 in rat lens: M.H. McGowan, et al.; J. Pharmacol. Exp. Ther. 289, 1559 (1999), Abstract
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1998), (Review), Abstract
Enhancement by bufalin of retinoic acid-induced differentiation of acute promyelocytic leukemia cells in primary culture: K. Yamada, et al.; Leuk. Res. 22, 589 (1998), Abstract
Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells: M. Watabe, et al.; Oncogene 16, 779 (1998), Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson; Life Sci. 63, 781 (1998), Abstract

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Bufalin

BML-AP303

Product Details

Handling & Storage

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