Bucladesine . sodium

Bucladesine . sodium, is a cell-permeable cyclic AMP (cAMP) analog that mimics the action of endogenous cAMP. It activates protein kinase A (PKA) and inhibits phosphodiesterases (PDEs), leading to elevated intracellular cAMP levels. This compound is widely used in research to study cAMP-mediated signaling pathways, inflammation, and wound healing.

Key features and applications include:

• Selective Inhibition: Targets ALK5/4/7 with high potency, effectively blocking Smad2/3 phosphorylation.
• cAMP Mimetic: Activates cAMP-dependent protein kinase (PKA) pathways.
• Phosphodiesterase Inhibitor: Enhances intracellular cAMP levels by resisting enzymatic breakdown.
• Cell-Permeable: Easily crosses cell membranes to exert intracellular effects.

Research Applications:

• Neuroscience: Investigates memory, learning, and synaptic plasticity.
• Cancer Biology: Explores cAMP’s role in cell proliferation and apoptosis.
• Dermatology: Used in models of acute skin inflammation.
• Cell Signaling: Studies second messenger systems and PKA activation.

Relevant disease states include:

• Inflammatory Skin Conditions: Demonstrates efficacy in reducing acute skin inflammation.
• Cognitive Disorders: Enhances spatial memory in preclinical models, supporting its use in neurodegenerative disease research.
• Wound Healing Impairments: Used to study and promote healing in damaged or diseased skin.
• Pain and Sensory Disorders: Investigated for its role in modulating pain perception via cAMP signaling.