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Bryostatin 1

BML-ST103

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PKC activator

A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε.

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Product Details

Appearance	White solid to colorless film.
CAS	83314-01-6
Couple Target	PKC
Couple Type	Activator
Formula	C₄₇H₆₈O₁₇
MW	905.0
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity: G. Sannier, et al.; Cell Rep. 36, 109643 (2021), Abstract
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes: A.O. Giarratana, et al.; Sci. Rep. 10, 19919 (2020), Abstract — Full Text
Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy: Pardons, M., Fromentin, R., et al.; Cell Rep. 29, 2783 (2019), Abstract
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique: Baxter, A. E., Niessl, J., et al.; Nat. Protoc. 12, 2029 (2017), Abstract
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts: Z. Szallasi, et al.; J. Biol. Chem. 269, 2118 (1994), Abstract
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin: H. Hennings, et al.; Carcinogenesis 8, 1343 (1987), Abstract

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Bryostatin 1

BML-ST103

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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