AMPIVIEW® RNA probes
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Product Details
| Alternative Name |
BCRP, ABCG2, MXR, CD338 |
|---|---|
| Application |
ICC, IHC (FS), IHC (PS), WB |
| Clone |
BXP-53 |
| Formulation |
Liquid. In PBS, containing 0.1% BSA, and 0.02% sodium azide. |
| Host |
Rat |
| Immunogen |
Recombinant mouse BCRP (breast cancer resistance protein; MXR) (aa 221-394). |
| Isotype |
IgG2a |
| Recommendation Dilutions/Conditions |
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.Immunohistochemistry (frozen sections, paraffin sections): Use 1:20 on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin., Western Blot: Use 1:20-1:50 dilution and HRP-labelled anti-rat IgG.Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human, Mouse |
| Specificity |
Recognizes an internal epitope of BCRP. |
| UniProt ID |
Q7TMS5 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice.: Taïb, S., Durand, J., et al.; Life Sci. Alliance 8, (2025), Application(s): IHC-Frozen / Reactant(s): Mouse, Abstract
- The net electrostatic potential and hydration of ABCG2 affect substrate transport: Gose, T., Aitken, H. M., et al.; Nat. Commun. 14, 5035 (2023), Abstract
- Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice.: Berezin, C. T., Bergum, N., et al.; Front. Pharmacol. 14, 1206104 (2023), Application(s): IHC / Reactant(s): Mouse, Abstract
- Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter.: Kozlosky, D., Doherty, C. L., et al.; Toxicol. Sci. , (2023), Reactant(s): Mouse, Abstract
- BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity: Wen, X., Kozlosky, D., et al.; Drug Metab. Dispos. 49, 629 (2021), Abstract
- Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone: Szilagyi, J. T., Gorczyca, L., et al.; Toxicol. Sci. 168, 394 (2019), Abstract
- Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling.: You, D., Wen, X., et al.; Mol. Neurobiol. 56, 6986 (2019), Application(s): WB / Reactant(s): Human, Abstract
- Brain region-specific regulation of histone acetylation and efflux transporters in mice: You, D., Shin, H. M., et al.; J. Biochem. Mol. Toxicol. 33, e22318 (2019), Abstract
- Identification of side population cells in human lung adenocarcinoma A549 cell line and elucidation of the underlying roles in lung cancer: Xie, T., Mo, L., et al.; Oncol. Lett. 15, 4900 (2018), Abstract
- Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2 Transporter in Term Human Placentas: Bircsak, K. M., Moscovitz, J. E., et al.; Drug Metab. Dispos. 46, 619 (2018), Abstract
- Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity: Szilagyi, J. T., Vetrano, A. M., et al.; Placenta 55, 29 (2017), Abstract
- Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier: H. Chapy, et al.; Br. J. Pharmacol. 173, 497 (2016), Abstract — Full Text
- Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter: Bircsak, K. M., Gupta, V., et al.; J. Pharmacol. Exp. Ther. 357, 103 (2016), Abstract
- Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid: Eldasher, L. M., Wen, X., et al.; Toxicology 306, 108 (2013), Abstract
- Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain: Cannon, R. E., Peart, J. C., et al.; PNAS 109, 15930 (2012), Abstract
- The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response: Higashikuni, Y., Sainz, J., et al.; Arterioscler. Thromb. Vasc. Biol. 32, 654 (2012), Abstract
- Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance: Agarwal, S., Elmquist, W. F., et al.; Mol. Pharm. 9, 678 (2012), Abstract
- Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2: André, P., Saubaméa, B., et al.; J. Cereb. Blood Flow Metab. 32, 1989 (2012), Abstract
- Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes: Tchaparian, E. H., Houghton, J. S., et al.; Drug Metab. Dispos. 39, 2387 (2011), Abstract
- Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen: Dietrich, C. G., Vehr, A. K., et al.; Int. J. Cancer 129, 546 (2011), Abstract
- Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity: Nagai, S., Takenaka, K., et al.; Cancer Res. 71, 1781 (2011), Abstract
- Cell-type selective phototoxicity achieved with chlorophyll-a derived photosensitizers in a co-culture system of primary human tumor and normal lung cells: Tracy, E. C., Bowman, M. J., et al.; Photochem. Photobiol. 87, 1405 (2011), Abstract
- MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport.: Zhang, F., Throm, S. L., et al.; Biochem. Pharmacol. 82, 24 (2011), Application(s): WB / Reactant(s): Human, Abstract
- Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice: A. Brenn, et al.; Int. J. Alzheimers Dis. 2011, 690121 (2011), Application(s): IHC using mouse brain tissue, Abstract — Full Text
- Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes: Swift, B., Brouwer, K. L., et al.; Mol. Pharm. 7, 491 (2010), Abstract
- Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver: Lee, J. K., Abe, K., et al.; Drug Metab. Dispos. 37, 1916 (2009), Abstract
- Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats: MacLean, C., Moenning, U., et al.; Drug Metab. Dispos. 36, 1249 (2008), Abstract
- The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2: Liu, W., Baer, M. R., et al.; Clin. Cancer Res. 13, 2463 (2007), Abstract
- Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor: Zhuang, Y., Fraga, C. H., et al.; Cancer Res. 66, 11305 (2006), Abstract
- The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria: J.W. Jonker, et al.; PNAS 99, 15649 (2002), Abstract — Full Text
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