The thymidine analogue BrdU (5-Bromo-2-Deoxyuridine), a derivative of uridine, can substitute for thymidine during DNA synthesis. The detection of BrdU incorporation into DNA provides a common method to quantify newly synthesized DNA and identify cells in the S-phase of the cell cycle. The use of BrdU incorporation in proliferation assays facilitates the study of DNA repair, sister chromatid exchange, and the cytokinetics of normal and neoplastic cells.
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Regulatory Status |
RUO – Research Use Only |
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