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bpV(HOpic)

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PTP inhibitor, PTEN Inhibitor

Protein phosphotyrosine phosphatase inhibitor.

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Appearance	Yellow crystalline solid.
Couple Target	PTEN, PTP
Couple Type	Inhibitor
Formula	K₂[VO(O₂)₂C₆H₄NO₃]
MW	347.2
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO or water. Note: This product is not stable in water. Starts decomposition immediately after solubilization. Rate of decomposition is slower in dry DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axi: M. Wang, et al.; iScience 25, 104009 (2022), Abstract
Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)P3 and actomyosin: X. Li, et al.; Mol. Cell. Neurosci. 123, 103772 (2022), Abstract
A Single Amino Acid Residue Regulates PTEN-Binding and Stability of the Spinal Muscular Atrophy Protein SMN: Rademacher, S., Detering, N. T., et al.; Cells 9, (2020), Abstract
A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors: Shiwarski, D. J., Tipton, A., et al.; J. Neurosci. 37, 3741 (2017), Abstract
Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein: A.M. Hartz, et al.; J. Pharmacol. Exp. Ther. 334, 467 (2010), Abstract — Full Text
Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction: K.T. Keyes, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1198 (2010), Abstract — Full Text
Bisperoxovanadium compounds are potent PTEN inhibitors: A.C. Schmid, et al.; FEBS Lett. 566, 35 (2004), Abstract
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994), Abstract — Full Text

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