BPDEtide

BML-P112

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Substrate for PKG and PKA

Sequence derived from bovine lung cGMP specific phosphodiesterase (cG-BPDE). Specific substrate for PKG, K_m=68 µM; K_m for PKA=320 µM, with no phosphorylation detected for CaMKII or PKC.

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Product Details

Alternative Name	cGMP-dependent protein kinase (PKG) substrate
Appearance	White to off-white solid.
Formula	C₆₈H₁₁₅N₂₃O₂₀
Formulation	Lyophilized.
MW	1574.8
Purity	≥97% (HPLC)
Sequence	H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH
Solubility	Soluble in water.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries: R.B. Thorpe, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 304, R734 (2013), Abstract — Full Text
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases: J.L. Colbran, et al.; J. Biol. Chem. 267, 9589 (1992), Abstract — Full Text
Studies of two different intrachain cGMP-binding sites of cGMP- dependent protein kinase: J.D Corbin & S.O. Døskeland; J. Biol. Chem. 258, 11391 (1983), Abstract — Full Text

Last modified: May 29, 2024

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BPDEtide

BML-P112

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Handling & Storage

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