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A substrate for the Kex2 endopeptidase from S. cerevisiae. This peptide is also a substrate for kallikrein 5 (KLK5), and a candidate substrate for the investigation of proteasome subunit function.
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Product Details
| Alternative Name |
Boc-LRR-AMC |
|---|---|
| Appearance |
White powder. |
| Formula |
C33H52N10O7 . 2 HCl |
| MW |
773.8 |
| Purity |
≥97% (HPLC) |
| Sequence |
Boc-LRR-AMC, Fluorogenic Substrate |
| Solubility |
Soluble in water (50mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model: Ross, J. M., Olson, L., et al.; Biomolecules 14, (2024), Reactant(s): Mouse, Abstract
- Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast: Sultana, S., Abdullah, M., et al.; Genetics 225, (2023), Abstract
- Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects: A.T. Anastasiadi, et al.; Front. Physiol. 13, 907444 (2022), Abstract
- The role of Cycloastragenol at the intersection of Nrf-2/ARE, telomerase, and proteasome activity: Yılmaz, S., Bedir, E., et al.; bioRxiv , (2022), Reactant(s): Human
- The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity: Yılmaz, S., Bedir, E., et al.; Free Radic. Biol. Med. 188, 105 (2022), Reactant(s): Human, Abstract
- Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring: V.L. Tzounakas, et al.; Redox Biol. 57, 102477 (2022), Abstract
- 20S proteasomes secreted by the malaria parasite promote its growth: E. Dekel, et al.; Nat. Commun. 12, 1172 (2021), Abstract — Full Text
- Amniotic Fluid Proteasome and Immunoproteasome in the Setting of Intra-Amniotic Infection, Inflammation, and Preterm Birth: C.A. Ware, et al.; Reprod Sci. 28, 2562 (2021), Abstract
- Cell cycle-dependent localization of the proteasome to chromatin: Y. Kito, et al.; Sci. Rep. 10, 5801 (2020), Abstract — Full Text
- Mass spectrometry-based absolute quantification of 20S proteasome status for controlled ex-vivo expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells: T. Menneteau, et al.; Mol. Cell. Proteomics 18, 744 (2019), Abstract
- Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria: F. Haider, et al.; Comp. Biochem. Physiol. A Mol. Integr. Physiol. 228, 81 (2018), Abstract
- mTORC1 accelerates retinal development via the immunoproteasome: J.H. Choi, et al.; Nat. Commun. 9, 2502 (2018), Abstract — Full Text
- A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect. 6, e105 (2017), Abstract — Full Text
- Proteasome properties of hemocytes differ between the whiteleg shrimp Penaeus vannamei and the brown shrimp Crangon crangon (Crustacea, Decapoda): S. Gotze, et al.; Cell Stress Chaperones 22, 879 (2017), Abstract — Full Text
- The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System: A.C.D. Fuchs, et al.; Structure 25, 834 (2017), Abstract — Full Text
- Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract
- Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system: C. McKinnon, et al.; Acta Neuropathol. 131, 411 (2016), Application(s): Determined trypsin-like activity, Abstract — Full Text
- Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol. 5, 205 (2015), Application(s): Fluorescent detection, Abstract
- FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis. 6, e1815 (2015), Application(s): Proteasome activity assays, Abstract — Full Text
- scyllo-Inositol promotes robust mutant Huntingtin protein degradation: A.Y. Lai, et al.; J. Biol. Chem. 289, 3666 (2014), Abstract — Full Text
- STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy: J.V. Ferreira, et al.; Autophagy 9, 1349 (2013), Abstract
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