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Boc-Gln-Ala-Arg-AMC

BML-P237

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Protease substrate

Fluorogenic substrate for trypsin (k_cat/K_m=2.0 x 10⁷ M^-1sec^-1; K_m=6.0 µM); matriptase/MT-SP1 and matriptase-2/TMPRSS6; PRSS12; KLK5; KLK11/PRSS20, KLK12, and KLK14; tryptase and thrombin; and dust mite allergen Der p 1. Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

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Product Details

Alternative Name	Boc-QAR-AMC
Appearance	Lyophilized solid.
Formula	C₂₉H₄₂N₈O₈
MW	630.7
Purity	≥99% (HPLC)
Sequence	N-tert-butoxycarbonyl-Gln-Ala-Arg-AMC [AMC=7-amino-4-methylcoumarin]
Solubility	Soluble in DMSO (≥10mM) or methanol (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation: Chvanov, M., Voronina, S., et al.; Autophagy 21, 210 (2025), Abstract
Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules: Zierke, L., John, D., et al.; Cell. Mol. Life Sci. 81, 207 (2024), Abstract
Rational design of humanized antibody inhibitors for cathepsin S: P.W. Yu, et al.; Arch. Biochem. Biophys. 751, 109849 (2024), Abstract
Hemin shows antiviral activity i>in vitro/i>, possibly through suppression of viral entry mediators: Unal, M. A., Bitirim, C. V., et al.; bioRxiv , (2022)
Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes: D. Lu, et al.; Hum. Cell 34, 771 (2021), Abstract
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro: Unal, M. A., Bitirim, C. V., et al.; Can. J. Physiol. Pharmacol. 99, 449 (2021), Abstract
Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen: S. Tiwari, et al.; Sci. Rep. 10, 3386 (2020), Abstract — Full Text
3-Cl-AHPC inhibits pro-HGF maturation by inducing matriptase/HAI-1 complex formation: F. Ye, et al.; J. Cell. Mol. Med. 23, 155 (2019), Abstract — Full Text
Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis: Wang, S., Ni, H. M., et al.; Autophagy 15, 1954 (2019), Abstract
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells: S.R. Wu, et al.; Sci. Rep. 7, 15101 (2017), Abstract — Full Text

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Alternative Name	Transmembrane protease serine 6, TMPRSS6
Source	Produced in Drosophila Schneider 2 (S2) cells. Recombinant human matriptase-2 (aa 78-811) is fused at the C-terminus to a V5-His-tag. Produced by plasmid transfection expression.

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Boc-Gln-Ala-Arg-AMC

BML-P237

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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