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Caspase inhibitor
Irreversible, cell permeable broad-spectrum caspase inhibitor.
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Product Details
| Alternative Name |
Caspase family inhibitor (fluoromethylketone) |
|---|---|
| Appearance |
White to off-white powder. |
| CAS |
187389-53-3 |
| Formula |
C11H18FNO5 |
| MW |
263.3 |
| Purity |
≥95% (TLC) |
| Sequence |
Boc-Asp(OMe)-fluoromethylketone |
| Solubility |
Soluble in DMSO or dimethyl formamide. |
| Technical Info / Product Notes |
The carboxyl groups are OMe ester form to enhance cell permeability. If purified enzyme is used, esterase should be added for the hydrolysis of the ester groups. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C. For long term storage keep aliquots at -70°C. |
|---|---|
| Handling |
Keep cool and dry. After reconstitution, prepare aliquots and store at -80°C. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore: Zhao, B., Ban, F., et al.; Cell Death Dis. 16, 482 (2025), Abstract
- Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract
- Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts: L.E. Metayer, et al.; Apoptosis 24, 145 (2019), Abstract — Full Text
- The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32: D. Vaudry, et. al.; PNAS 97, 13390 (2000), Abstract — Full Text
- A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation: S.R. D’Mello, et al.; J. Neurochem. 70, 1809 (1998), Abstract
- Caspase inhibitor BD-fmk distinguishes transforming growth factor β-induced apoptosis from growth inhibition: T.L. Brown, et al.; Cell Growth Differ. 9, 869 (1998), Abstract
- Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury: Y. Cheng, et al.; J. Clin. Invest. 101, 1992 (1998), Abstract — Full Text
- Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996), Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Specific Protocol
Prepare a 20 mM stock solution of the caspase inhibitor in DMSO. Add 1 µl of above stock solutions to 1 ml of culture medium containing cells to give 20 mM final concentration. DMSO concentration above of 0.2 % may cause cellular toxicity thus masking the effect of the ICE-protease inhibitor Boc-D(OMe)-FMK. For in vivo experiments extending for 12 to 48 hours, fresh inhibitor may have to be added (injected) due to inactivation by reaction with cysteine protease.
Certificate of Analysis
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SDS
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