Potent (IC50=40nM) and selective (290X selectivity over other PDE isoforms) inhibitor of phosphodiesterase Type II (PDE2). Displayed no significant level of binding to neither a collection of 54 receptors and ion channels, nor to a panel of 30 kinases. BML-288 demonstrated no inhibition of 5-lipoxygenase (5-LO) or cyclooxygenase (COX-1). BML-288 is more potent and selective than EHNA (BML-PD129).
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Regulatory Status |
RUO – Research Use Only |
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