BML-282

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UCH inhibitor

Novel inhibitor of ubiquitin C-terminal hydrolase L1 (IC₅₀ = 0.81 µM). It displays 21-fold greater selectivity over UCH-L3 (IC₅₀ = 17 µM).

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Alternative Name	N-(3,4-Dichlorobenzyl)-5-bromoisatin O-acetyloxime
Appearance	Yellow solid.
Couple Target	Deconjugating enzyme [DCE], UCH
Couple Type	Inhibitor
Formula	C₁₇H₁₁BrCl₂N₂O₃
MW	442.1
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (5mg/ml with warming) or dimethyl formamide (10mg/ml with warming).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.
Handling	Store tightly sealed. Allow product to equilibrate to room temperature prior to opening.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Mechanisms, biology and inhibitors of deubiquitinating enzymes: K.R. Love, et al.; Nat. Chem. Biol. 3, 697 (2007), Abstract

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