BML-281

BML-GR361

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HDAC6 inhibitor

Selective HDAC6 inhibitor (IC₅₀=0.002nM). IC₅₀values for other HDACs are 271, 252, 0.42, 6851 and 90.7 nM for HDACs 1,2,3,8 and 10 respectively. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC₅₀s in the 0.1-0.6µM range).

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Product Details

Alternative Name	N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide
Appearance	Off-white solid.
CAS	1045792-66-2
Couple Target	HDAC, HDAC6
Couple Type	Inhibitor
Formula	C₂₂H₃₀N₄O₆
MW	446.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (15 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months.
Short Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys. 60, 173 (2011), Abstract — Full Text
Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6: A.P. Kozikowski, et al.; J. Med. Chem. 51, 4370 (2008), Abstract — Full Text

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Source	Produced in insect cells. Produced in a baculovirus expression system.

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BML-281

BML-GR361

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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