BML-280

BML-ST371

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PLD inhibitor

Potent and selective inhibitor of phospholipase D2 (PLD2) in cellular (PLD1 IC₅₀ = 1900nM Calu-1 cells; PLD2 IC₅₀ = 90nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC₅₀ = >20’000nM; hPLD2 IC₅₀ = 500nM) assays.

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Product Details

Alternative Name	N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)quinoline-3-carboxamide, VU0285655-1
Appearance	Off-white solid.
CAS	1158347-73-9
Couple Target	PLD
Couple Type	Inhibitor
Formula	C₂₅H₂₇N₅O₂
MW	429.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity: R. Lavieri, et al.; Bioorg. Med. Chem. Lett. 19, 2240 (2009), Abstract

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BML-280

BML-ST371

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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