BML-279

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PLD inhibitor

Dual phospholipase D1/D2 (PLD1/PLD2) inhibitor in cellular assays (PLD1 IC₅₀=8nM in Calu-1 cells; PLD2 IC₅₀=42nM in HEK293-gfpPLD2 cells).

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Alternative Name	N-[(1-[4-(2-Oxo-3H-benzimidazol-1-yl)-piperidin-1-yl]-ethyl]quinoline-3-carboxamide
Appearance	White solid.
Couple Target	PLD
Couple Type	Inhibitor
Formula	C₂₄H₂₅N₅O₂
MW	415.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity: J.A. Lewis, et al.; Bioorg. Med. Chem. Lett. 19, 1916 (2009), Abstract

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