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BML-278

BML-GR359

1 citation

  • BML-GR359-0005   —   5 mg
    $100.00
  • BML-GR359-0025   —   25 mg
    $425.00

Novel Sirt activator structurally based on a dihydropyridine scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) =1μM for Sirt1 with weaker effect on Sirt2 and Sirt3 (25 and 50μM respectively). The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells.

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Regulatory Status

RUO – Research Use Only