BML-277

BML-EI388

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Chk inhibitor

BML-277 is a highly selective inhibitor of Chk2 (IC₅₀=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC₅₀= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.

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Product Details

Alternative Name	Chk2 Inhibitor II
Appearance	Off-white solid.
CAS	516480-79-8
Couple Target	Chk
Couple Type	Inhibitor
Formula	C₂₀H₁₄ClN₃O₂
MW	363.8
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells: I. Kudo, et al.; Exp. Cell. Res. 16, 30205 (2016), Application(s): Cell culture, cervical tumor cells, Abstract
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage: Y. Pereg, et al.; Mol. Cell. Biol. 26, 6819 (2006), Abstract — Full Text
Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles: K.L. Arienti, et al.; J. Med. Chem. 48, 1873 (2005), Abstract

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BML-277

BML-EI388

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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