BML-275

BML-EI369

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AMPK inhibitor

Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (K_i=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

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Product Details

Alternative Name	Compound C, Dorsomorphin
Appearance	Yellow solid.
CAS	866405-64-3
Couple Target	Activin receptor, AMPK, BMP receptor
Couple Type	Inhibitor
Formula	C₂₄H₂₅N₅O
MW	399.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (3mg/ml, warm)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide – AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system: U. Karunakaran, et al.; Redox Biol. 69, 102994 (2023), Abstract
PRKAG2.2 is essential for FoxA1+ regulatory T cell differentiation and metabolic rewiring distinct from FoxP3+ regulatory T cells: Mandatori, S., Liu, Y., et al.; Sci. Adv. 9, eadj8442 (2023), Abstract
AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway: Kothari, V., Babu, J. R., et al.; PLoS One 17, e0266472 (2022), Abstract
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase: B. Zhou, et al.; Cell Rep. 37, 109785 (2021), Abstract
Stereospecific inhibition of AMPK by (R)-crizotinib induced changes to the morphology and properties of cancer and cancer stem cell-like cells: T.H. Kim, et al.; Eur. J. Pharmacol. 911, 174525 (2021), Abstract
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system: U. Karunakaran, et al.; Redox Biol. 45, 102029 (2021), Application(s): Treatment of rat INS-1 insulinoma cell line, Abstract — Full Text
SIRT1-Dependent Upregulation of BDNF in Human MicrogliaChallenged with Aβ: An Early but Transient Response Rescuedby Melatonin: G.I. Caruso, et al.; Biomedicines 9, 466 (2021), Abstract
Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway: B.H. Chen, et al.; Sci. Rep. 10, 5163 (2020), Abstract — Full Text
SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence: S. Merlo, et al.; Biomolecules 10, 364 (2020), Abstract
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms: M. Panse, et al.; PLoS One 13, e0198016 (2018), Abstract — Full Text

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BML-275

BML-EI369

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