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BML-210

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HDAC inhibitor

HDAC inhibitor developed at Enzo Life Sciences. Inhibits HDAC activity in HeLa nuclear extracts (IC₅₀=5-10µM).

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Appearance	Tan solid.
CAS	537034-17-6
Couple Target	HDAC
Couple Type	Inhibitor
Formula	C₂₀H₂₅N₃O₂
MW	339.4
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml, warm)

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2: Jayathilaka, N., Han, A., et al.; Nucleic Acids Res. 40, 5378 (2012), Abstract
The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines: J. Savickiene et al.; Eur J Pharmacol 549, 9 (2006), Abstract
Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia: D. Herman, et al.; Nature Chem. Biol. 10, 551 (2006), Abstract

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