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BML-111

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Lipoxin receptor ligand

Potent lipoxin A₄ agonist, equiactive as LXA₄ in inhibition of LTB₄ induced PMNL chemotaxis (IC₅₀=5 nM).

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Alternative Name	5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
Appearance	White solid.
Couple Target	Lipoxin receptor
Couple Type	Ligand
Formula	C₈H₁₆O₅
MW	192.2
Purity	≥99%
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms: F. Lin, et al.; Reprod. Toxicol. 34, 677 (2012), Application(s): Injection of BML-111 in low-dose endotoxin induced preeclampsia in rats, Abstract
Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of anti-angiogenesis: Y. Chen, et al.; Mol. Cancer Res. 9, 2164 (2010), Application(s): Injection of BML-111 in tumor-transplanted mice, Abstract — Full Text
BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis: L. Zhang, et al.; Inflamm. Res. 57, 157 (2008), Application(s): Injection of BML-111 in a murine model of collagen-induced arthritis, Abstract
Protective effects of BML-111, a lipoxin A4 receptoir agonist, on carbon tetrachloride-induced liver injury in mice: L. Zhang, et al.; Hepatol. Res. 37, 948 (2007), Application(s): Injection of BML-111 a murine model of carbon tetrachloride (CCl4)-induced acute liver injury, Abstract

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