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Bmf (mouse/rat) monoclonal antibody (17A9)

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This antibody is covered by our Worry-Free Guarantee.

Alternative Name	Bcl-2-modifying factor
Application	ELISA, Flow Cytometry, IP, WB
Application Notes	Detects bands of ~25kDa and ~30kDa by Western blot, corresponding to endogenous Bmf and Bmf_L.
Clone	17A9
Crossreactivity	Does not cross-react with human Bmf.
Formulation	Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant full length mouse Bmf and synthetic peptides corresponding to aa 13-27 (D13VFQSEDGEPGTQPG27) and aa 112-126 (A112GSPLGEQPPEGQFL126) of mouse Bmf.
Isotype	IgG2a
Recommendation Dilutions/Conditions	Western Blot (1-2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Mouse, Rat
UniProt ID	Q91ZE9
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Regulatory Status	RUO – Research Use Only

Bmf Facilitates Protein Degradation and Reduces Beclin1 Ubiquitination to Inhibit Autophagy Independent of mTOR: Delgado-Vergas, M., Fort, S., et al.; bioRxiv , (2020)
Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression: Hayakawa, K., Formica, A. M., et al.; J. Exp. Med. 213, 3007 (2016), Abstract
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf: Baumgartner, F., Woess, C., et al.; Oncogene 32, 621 (2013), Abstract
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program: D. Ren, et al.; Science 330, 1390 (2010), Abstract — Full Text
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis: F. Grespi, et al.; Cell Death Differ. 17, 1672 (2010), Abstract — Full Text
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins.: D. Mérino, et al.; J. Cell. Biol. 186, 355 (2009), Application(s): WB post IP, Abstract
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development: V. Labi, et al.; J. Exp. Med. 205, 641 (2008), Abstract — Full Text
Broad degradation of proapoptotic proteins with the conserved Bcl-2 homology domain 3 during infection with Chlamydia trachomatis: S. Ying, et al.; Infect. Immun. 73, 1399 (2005), Abstract — Full Text

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