Blocking Peptide for PAb to Caspase-12 (NT) (Prod. No. PSC-2325)

Synthetic peptide corresponding to aa 2-17 of mouse caspase-12.
The peptide is used for blocking the antibody activity of caspase-12 (Prod. No. PSC-2325). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C

Caspase-14 possesses an unusally short prodomain (therefore also called mini-ICE or MICE) and is highly expressed in embryonic tissue and epidermal keratinocytes. Caspase-14 is not activated during apoptosis induced by UV irradiation or cytotoxic substances and is thought to play an important role in the physiological cell death of keratinocytes leading to skin barrier formation.