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Blm10 (Saccharomyces cerevisiae) polyclonal antibody

BML-PW0570

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Blm10 (mammalian homolog PA200) is a large 246kDa regulatory protein that binds to the 20S proteasome core particle (CP). Blm10 recognizes pre-activated open gate CP which is assumed to exist in equilibrium with inactive closed gate CP. Blm10 distinguishes gate conformations, regulates CP activation, and has been shown to be involved in CP maturation.

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This antibody is covered by our Worry-Free Guarantee.

the reaction is terminated by addition of the stop solution

Product Details

Alternative Name	Blm3, PA200 homolog
Application	WB
Formulation	Liquid. Neat serum diluted in PBS containing 0.01% sodium azide.
Host	Rabbit
Immunogen	Recombinant N-terminal protein fragment (aa 1-157) of Saccharomyces cervisiae Blm10.
Recommendation Dilutions/Conditions	Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Saccharomyces cerevisiae
UniProt ID	P43583
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. Dilute with PBS, pH 7.2-7.4, containing 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at +4°C, do not freeze and use within 1 month.
Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Structure of Blm10:13S proteasome intermediate reveals parallel assembly pathways for the proteasome core particle: Kaur, M., Chen, X., et al.; bioRxiv , (2024), Reactant(s): Saccharomyces cerevisiae
Yeast PI31 inhibits the proteasome by a direct multisite mechanism: S. Rawson, et al.; Nat. Struct. Mol. Biol. 29, 791 (2022), Reactant(s) Saccharomyces cerevisiae, Abstract
Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29: P. Wani, et al.; Sci. Rep. 6, 27873 (2016), Application(s): Immunoblotting, Abstract — Full Text
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis: J.J. Chia, et al.; J. Clin. Invest. 126, 4331 (2016), Application(s): Mouse injections treatments, Abstract — Full Text
Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association: P.S. Wani, et al.; Nat. Commun. 6, 6384 (2015), Abstract

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Blm10 (Saccharomyces cerevisiae) polyclonal antibody

BML-PW0570

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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