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Biotinyl-DEVD-CHO

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Inhibitor of caspase-3 and -7

Reversible inhibitor of caspase-3 and -7. Useful for the purification or extract depletion of caspase-3 in conjunction with streptavidin conjugates.

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Alternative Name	Caspase-3 inhibitor (aldehyde), Caspase-7 inhibitor (aldehyde), CPP32 affinity reagent
Appearance	White powder.
Formula	C₂₈H₄₂N₆O₁₂S
Formulation	Lyophilized.
MW	686.7
Peptide Content	65-90%.
Purity	≥99% (HPLC)
Sequence	Biotinyl-Asp-Glu-Val-Asp-CHO
Solubility	Soluble in 50% acetic acid with agitation (1mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Packaged under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract

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