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Biliverdin Reductase polyclonal antibody

ADI-OSA-450

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The phosphoprotein BVR (Biliverdin Reductase) is an oxireductase which catalyzes the reduction of the gamma-meso bridge of Biliverdin to Bilirubin. BVR is unique among all enzymes characterized to date because BVR has dual pH/dual cofactor requirements. The reductase is highly conserved in its primary structure and molecular properties and uses NADH in the acidic range (peak activity at pH~6.7), whereas NADPH is utilized in the basic range (peak activity at pH ~8.7).

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This antibody is covered by our Worry-Free Guarantee.

Biliverdin Reductase polyclonal antibody Western blot — Western blot analysis of Biliverdin Reductase, pAb (Prod. No. ADI-OSA-450): Lane 1: MW Marker, Lane 2: Biliverdin Reductase Protein (rat) (recombinant) (Prod. No. ADI-OSP-450), Lane 3: Rat-2 Cell Lysate, Lane 4: 3T3 Cell Lysate (Prod. No. ADI-LYC-3T100), Lane 5: PC-12 Cell Lysate (Prod. No. ADI-LYC-PC100), Lane 6: HO-1 Protein (rat) (recombinant) (Prod. No. ADI-SPP-730)

Product Details

Alternative Name	BLVR
Application	IP, WB
Application Notes	Detects bands of ~33kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
GenBank ID	M81681
Host	Rabbit
Immunogen	Recombinant rat Biliverdin Reductase.
Purity Detail	Ammonium sulfate precipitation purified.
Recommendation Dilutions/Conditions	Immunoprecipitation (1:100)Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	E. coli, Mouse, Rat
UniProt ID	P46844
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Induction of BVR-A Expression by Korean Red Ginseng in Murine Hippocampal Astrocytes: Role of Bilirubin in Mitochondrial Function via the LKB1-SIRT1-ERRα Axis: S. Moon, et al.; Antioxidants 11, 1742 (2022), Abstract
Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.: Gnatenko, D. V., Bahou, W. F., et al.; Free Radic. Biol. Med. 164, 164 (2021), Application(s): WB, Abstract
Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1-/- Mice: Impact on Redox Status and Metabolism.: Bortolussi, G., Shi, X., et al.; Antioxidants (Basel) 10, (2021), Application(s): WB / Reactant(s): Mouse, Abstract
Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice.: Stec, D. E., Hinds, T. D., et al.; Biomolecules 10, (2020), Application(s): WB / Reactant(s): Mouse, Abstract
CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation: Gordon, D. M., Adeosun, S. O., et al.; Arch. Biochem. Biophys. 672, 108072 (2019), Abstract
Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells: Adeosun, S. O., Gordon, D. M., et al.; Am. J. Physiol. Renal Physiol. 315, F323 (2018), Abstract
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.: Vanden Heuvel, J. P., Drummond, H. A., et al.; J. Biol. Chem. 291, 25179 (2016), Application(s): IF / Reactant(s): Mouse, Abstract