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(-)-Bicuculline methiodide

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GABA_A receptor agonist

A water soluble analog of bicuculline, the classic GABA_A antagonist.

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Appearance	Pale yellow solid.
CAS	40709-69-1
Couple Target	GABA receptor
Couple Type	Ligand
Formula	C₂₁H₂₀INO₆
MW	509.3
Purity	≥98% (HPLC)
Solubility	Soluble in water (10mg/ml) or DMSO (30mg/ml).
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition: Wang, L., Yang, Z., et al.; Nat. Commun. 15, 6209 (2024), Abstract
ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning: Y. Xu, et al.; Neuropsychopharmacology , (2021), Abstract
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits: Bridi, M. C. D., Zong, F. J., et al.; Neuron 105, 621 (2020), Abstract
Disruption of NMDAR Function Prevents Normal Experience-Dependent Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex: Rodriguez, G., Mesik, L., et al.; J. Neurosci. 39, 7664 (2019), Abstract
Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling: Chokshi, V., Gao, M., et al.; Neuron 104, 736 (2019), Abstract
Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice: Rodriguez, G., Chakraborty, D., et al.; Cell Rep. 24, 3433 (2018), Abstract

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