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Bepridil . hydrochloride

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Ca²⁺ channel inhibitor

Non-selective Ca²⁺ channel blocker. Stimulates the binding of 1,4-dihydropyridine-based drugs to Ca²⁺ channels. Inhibits Na⁺/Ca²⁺ exchange.

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Alternative Name	1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane . HCl
Appearance	White to off-white solid.
CAS	74764-40-2
Couple Target	Calcium channel
Couple Type	Inhibitor
Formula	C₂₄H₃₄N₂O . HCl
MI	14: 1150
MW	366.6 . 36.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol; insoluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Store tightly sealed.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Nisin, a food preservative produced by Lactococcus lactis, affects the localization pattern of intermediate filament protein in HaCaT cells: N. Kitagawa, et al.; Anat. Sci. Int. 94, 163 (2019), Abstract — Full Text
Intracellular Ca2+ mediates the cytotoxicity induced by bepridil and benzamil in human brain tumor cells: Y.S. Lee, et al.; Cancer Lett. 88, 87 (1995), Abstract
Bepridil as an antisickling agent: membrane internalization and cell rigidity: R.M. Johnson, et al.; Am. J. Hematol. 46, 310 (1994), Abstract
Drug action and cellular calcium regulation: R. Janis, et al.; Adv. Drug Res. 16, 309 (1987)
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes: J.P. Galizzi, et al.; J. Biol. Chem. 261, 1393 (1986), Abstract — Full Text

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