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Benzamil . HCl

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Na⁺ channel blocker

Derivative of amiloride (Prod. No. BML-CA200). Potent sodium channel blocker.

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Alternative Name	Benzylamiloride . HCl, N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide . HCl
Appearance	Yellow solid.
CAS	161804-20-2
Couple Target	Sodium channel
Couple Type	Blocker
Formula	C₁₃H₁₄ClN₇O . HCl
MW	356.2
Purity	≥98% (HPLC)
Solubility	Soluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits: Lee, S. K., Boron, W. F., et al.; Am. J. Physiol. Renal Physiol. 304, F883 (2013), Abstract
Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels: M. Nishimura, et al.; Am. J. Physiol. 276, R1416 (1999), Abstract
Modulation of cardiac performance by amiloride and several selected derivatives of amiloride: G.N. Pierce, et al.; J. Pharmacol. Exp. Ther. 265, 1280 (1993), Abstract
Structure-activity relations of amiloride and its analogues in blocking the mechanosensitive channel in Xenopus oocytes: J.W. Lane, et al.; Br. J. Pharmacol. 106, 283 (1992), Abstract
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman & E.J. Cragoe; J. Membr. Biol. 105, 1 (1988), Abstract

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