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BEC . ammonium salt

ALX-270-345

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Arginase inhibitor

Slow-binding competitive inhibitor of arginase I (K_i=0.4-0.6µM & K_D=2.22µM for recombinant rat liver arginase) and arginase II (K_i=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation.

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Product Details

Alternative Name	S-(2-Boronoethyl)-L-cysteine . NH4
Appearance	White to off-white powder.
CAS	63107-40-4 (non-salt)
Couple Target	Arginase
Couple Type	Inhibitor
Formula	C₅H₁₁BNO₄S . NH₄
MW	192.0 . 18.0
Purity	≥95% (TLC)
Solubility	Soluble in water (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Keep under inert gas. Keep cool and dry.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation: J. A. Scott, et al.; J. Appl. Physiol. (1985) 118, 1229 (2015), Application(s): Intratracheal Instillation , Abstract — Full Text
Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium: A.S. Jung, et al.; Am. J. Physiol. Heart Circ. Physiol. 290, H1756 (2006), Abstract
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism: J. Steppan, et al.; PNAS 103, 4759 (2006), Abstract — Full Text
Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin: L.A. Holowatz, et al.; Am. J. Physiol. Heart Circ. Physiol. 291, H2965 (2006), Abstract
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005), Abstract — Full Text
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels: D.E. Berkowitz, et al.; Circulation 108, 2000 (2003), Abstract — Full Text
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum: N.N. Kim, et al.; Biochemistry 40, 2678 (2001), Abstract
Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori & D.E. Ash; Biochemistry 40, 9356 (2001), Abstract
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation: L.H. Wei, et al.; PNAS 98, 9260 (2001), Abstract — Full Text
Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase: J.D. Cox, et al.; Biochemistry 40, 2689 (2001), Abstract

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BEC . ammonium salt

ALX-270-345

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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