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Members of the TNF superfamily regulate immune responses and induce apoptosis. Two members of this family were identified and designated BAFF and April, respectively. Three receptors for BAFF were identified; these include: BCMA (B-cell maturation protein), TACI, and BAFF-R. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B-Cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B-Cell associated autoimmune diseases.
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Immunofluorescence of BCMA in human spleen cells with BCMA antibody at 10µg/ml.
Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with BCMA antibody at 5µg/ml.
Immunohistochemistry analysis of BCMA in human spleen cells with BCMA antibody at 10µg/ml.
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RUO – Research Use Only |
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