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BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | TNFRSF 17, B cell maturation protein, CD269 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1. |
| Alternative Name | B cell maturation protein, TNFRSF 17, CD269 |
|---|---|
| Application | ELISA, Flow Cytometry, FUNC, ICC, WB |
| Host | Rat |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | B cell maturation protein, TNFRSF 17, CD269 |
|---|---|
| Application | Flow Cytometry |
| Host | Rat |
| Isotype | IgG1 |
| Species Reactivity | Human |