Home Shop BAY 61-3606 . hydrochloride

BAY 61-3606 . hydrochloride

ALX-270-479

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ALX-270-479-M001 — 1 mg

$63.00

BAY 61-3606 . hydrochloride quantity
ALX-270-479-M005 — 5 mg

$238.00

BAY 61-3606 . hydrochloride quantity
ALX-270-479-M025 — 25 mg

$920.00

BAY 61-3606 . hydrochloride quantity

Syk inhibitor

Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.

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Product Details

Alternative Name	2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl
Appearance	Yellow solid.
CAS	648903-57-5
Couple Target	Syk
Couple Type	Inhibitor
Formula	C₂₀H₁₈N₆O₃ . HCl
Identity	Determined by MS.
MW	390.4 . 36.5
Purity	≥98% (HPLC(UV))
Solubility	Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck: S. Luangdilok, et al.; Cancer Res. 67, 7907 (2007), Abstract
Kinase inhibitors and airway inflammation: I.M. Adcock, et al.; Eur. J. Pharmacol. 533, 118 (2006), Abstract
Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases: P. Luskova & P. Draber; Curr. Pharm. Des. 10, 1727 (2004), Abstract
A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells: K. Nakashima, et al.; Eur. J. Pharmacol. 505, 223 (2004), Abstract
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents: N. Yamamoto, et al.; J. Pharmacol. Exp. Ther. 306, 1174 (2003), Abstract — Full Text

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BAY 61-3606 . hydrochloride

ALX-270-479

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