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BAY 43-9006

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Broad-spectrum kinase inhibitor

Broad-spectrum kinase inhibitor.

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Alternative Name	N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide, Sorafenib
Appearance	White to off-white solid.
CAS	284461-73-0
Couple Target	Kinase
Couple Type	Inhibitor
Formula	C₂₁H₁₆ClF₃N₄O₃
Identity	Identity determined by 1H-NMR.
MW	464.8
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Sorafenib induces pigmentation via the regulation of β-catenin signalling pathway in melanoma cells: K. Kim, et al.; Exp. Dermatol. 31, 57 (2022), Application(s): Pigmentation studies on HM3KO melanoma cells, Abstract
Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers: M. Meßner, et al.; Sci. Rep. 11, 11185 (2021), Abstract — Full Text
Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma: M. Mebner, et al.; FASEB J. 34, 11860 (2020), Abstract — Full Text
The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007), Abstract
Sorafenib (BAY 43-9006, Nexavar((R))), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005), Abstract

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