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BAY 11-7085

BML-EI279

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NF-κB inhibitor

An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC₅₀=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.

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Product Details

Appearance	White solid.
CAS	196309-76-9
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₁₃H₁₅NO₂S
MW	249.3
Purity	≥99% (TLC)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis: L.C. Chang, et al.; Cancer Lett. 416, 124 (2018), Abstract
Drug-perturbation-based stratification of blood cancer: S. Dietrich, et al.; J. Clin. Invest. 128, 427 (2017), Abstract — Full Text
TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms: W.B. Fang, et al.; PLoS One 10, e0135063 (2015), Abstract — Full Text
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress: K.S. Lee, et al.; Thorax 71, 52 (2015), Application(s): Cell culture , Abstract — Full Text
An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production: Kim, Y. I., Park, K., et al.; Mol. Cell. Biol. 34, 4368 (2014), Abstract
Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy: DeArmond, P. D., West, G. M., et al.; J. Biomol. Screen. 15, 1051 (2010), Abstract
In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas: P.A. Robe, et al.; Clin. Cancer Res. 10, 5595 (2004), Abstract
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001), Abstract
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis: U. Koedel, et al.; J. Infect. Dis. 182, 1437 (2000), Abstract
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997), Abstract

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BAY 11-7085

BML-EI279

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