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NF-κB inhibitor
Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.
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Product Details
| Alternative Name |
(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
19542-67-7 |
| Couple Target |
NF-kappaB |
| Couple Type |
Inhibitor |
| Formula |
C10H9NO2S |
| MW |
207.2 |
| Purity |
≥99% (HPLC) |
| Solubility |
Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. Keep under inert gas. |
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation: Prevost, M., Crépin, D., et al.; J. Neuroinflammation 22, 198 (2025), Abstract
- TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy: V. Wang, et al.; PLoS One 17, e0271950 (2022), Abstract
- Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract — Full Text
- Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract — Full Text
- Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells: Demirel, I., Persson, A., et al.; Front. Cell. Infect. Microbiol. 8, 81 (2018), Abstract
- The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-κB and Sp1 Signaling Pathways: Chen, X., Zhang, Q., et al.; J. Virol. 91, (2017), Abstract
- N,N-Dimethylacetamide Significantly Attenuates LPS- and TNFα-Induced Proinflammatory Responses Via Inhibition of the Nuclear Factor Kappa B Pathway: Pekson, R., Poltoratsky, V., et al.; Mol. Med. 22, 747 (2016), Abstract
- Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production: Gao, Y., Zhang, Y., et al.; Oncotarget 7, 80275 (2016), Application(s): In Vitro, Abstract
- Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages: D.K. Lee, et al.; FEBS Lett. 589, 2859 (2015), Application(s): Cell Culture, Abstract
- Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis: Kindrachuk, J., Ork, B., et al.; Antimicrob. Agents Chemother. 59, 1088 (2015), Abstract
- Sterile-filtered saliva is a strong inducer of IL-6 and IL-8 in oral fibroblasts: B. Cvikl, et al.; Clin. Oral. Investig. 19, 385 (2015), Application(s): Treatment of fibroblasts in culture, Abstract
- Effect of Glutamate on Brain Iron Metabolism and the Regulation Mechanism: P. Yu, et al.; J. Drug Metab. Toxicol. 6, 190 (2015), Application(s): Cell culture , Full Text
- TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer: J.B. Jeong, et al.; Int. J. Mol. Sci. 16, 10411 (2015), Application(s): Cell Culture, Abstract — Full Text
- Anticancer activity of protocatechualdehyde in human breast cancer cells: Choi, J., Jiang, X., et al.; J. Med. Food 17, 842 (2014), Abstract
- Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus: Hou, J., Wang, L., et al.; Virol. J. 9, 165 (2012), Abstract
- Interleukin-1 exerts distinct actions on different cell types of the brain in vitro: An, Y., Chen, Q., et al.; J. Inflamm. Res. 2011, 11 (2011), Abstract
- Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells: Lim, D. M., Wang, M. L., et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 301, G91 (2011), Abstract
- Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways: Lambrianides, A., Carroll, C. J., et al.; J. Immunol. 184, 6622 (2010), Abstract
- Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis: Shant, J., Cheng, K., et al.; Exp. Cell Res. 315, 432 (2009), Abstract
- The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells: Olsnes, A. M., Ersvaer, E., et al.; Br. J. Haematol. 145, 761 (2009), Abstract
- TLR3-mediated NF-{kappa}B signaling in human esophageal epithelial cells: Lim, D. M., Narasimhan, S., et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 297, G1172 (2009), Abstract
- Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death: T.M. Kauppinen & R.A. Swanson; J. Immunol. 174, 2288 (2005), Abstract — Full Text
- Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001), Abstract
- Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells: S.A. Keller, et al.; Blood 96, 2537 (2000), Abstract
- Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways: M.M. Remacle-Bonnet, et al.; Cancer Res. 60, 2007 (2000), Abstract
- Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem. 275, 1887 (2000), Abstract — Full Text
- Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997), Abstract — Full Text
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