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Bax polyclonal antibody

ADI-AAS-040

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Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterized by the presence of at least one Bcl-2 homology (BH) domains. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes where it inserts and mediates the release of cytochrome c. This activates caspase-3 and perpetuates the apoptotic cascade.

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Product Details

Alternative Name	BCL2L4, BCL2-associated X protein
Application	WB
Application Notes	Detects a band of ~22kDa by Western blot.
Formulation	Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
GenBank ID	L22473
Host	Rabbit
Immunogen	Synthetic peptide corresponding to a portion of human Bax.
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from rabbit serum.
Species Reactivity	Bovine, Human, Monkey, Mouse, Porcine, Rabbit, Rat
UniProt ID	Q07812
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3: O. Ham, et al.; Stem Cell Res. Ther. 6, 147 (2015), Application(s): Western blot, Abstract — Full Text
Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury: Y. Xiao, et al.; Plast. Aesthet. Res. 2, 332 (2015), Application(s): Western blot, Full Text
Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits: Y. Wang, et al.; Molecules 20, 22395 (2015), Application(s): Western blot / Reactant(s): Rabbit, Abstract — Full Text