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Bax and Bak operate in both the endoplasmatic reticulum (ER) and mitochondria as an essential gateway for selected apoptotic signals. A role for Bcl-2 at the ER has been suggested earlier as Bcl-2 may regulate calcium fluxes between the ER and the mitochondria. For a review on Ca2+ and its role in apoptosis.
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IHC staining of human lung cancer using anti-Bax antibody. Formalin fixed human lung cancer slices were were stained with the antibody at 3 µg/ml.
| Regulatory Status |
RUO – Research Use Only |
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Last modified: May 29, 2024