Baicalein

BML-EI106

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Lipoxygenase inhibitor

Inhibits cellular Ca²⁺ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC₅₀=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC₅₀=36µM).

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Product Details

Alternative Name	5,6,7-Trihydroxyflavone
Appearance	Yellow to yellow-green crystalline powder.
CAS	491-67-8
Couple Target	Endopeptidase, Lipoxygenase
Couple Type	Inhibitor
Formula	C₁₅H₁₀O₅
MI	14: 942
MW	270.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Subject to oxidation.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1β Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation: Kwak, D. W., Park, D., et al.; Biomedicines 9, (2021), Abstract
Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells: J. Park, et al.; Biochim. Biophys. Acta Mol. Cell. Res. 1866, 329 (2019), Application(s): Treatment onf SW480 cells in culture, Abstract
Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock: S.Y. Kwon, et al.; Sci. Rep. 9, 5936 (2019), Abstract — Full Text
Wogonin, a plant flavone from Scutellariae radix, attenuated ovalbumin-induced airway inflammation in mouse model of asthma via the suppression of IL-4/STAT6 signaling: Ryu, E. K., Kim, T. H., et al.; J. Clin. Biochem. Nutr. 57, 105 (2015), Abstract
In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment: Bissinger, R., Malik, A., et al.; Toxins (Basel) 6, 2771 (2014), Abstract
Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor: T. Tarrago, et al.; Bioorg. Med. Chem. 16, 7516 (2008), Abstract
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile: Y. Chang, et al.; Neurosci. Lett. 441, 16 (2008), Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007), Abstract
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases: J. D. Deschamps, et al.; Bioorg. Med. Chem. 14, 4295 (2006), Abstract
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review), Abstract

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Baicalein

BML-EI106

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