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Bafilomycin B₁

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V-ATPase inhibitor

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase.

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Appearance	Yellow solid.
CAS	88899-56-3; 80112-34-1
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₄₄H₆₅NO₁₃
Identity	Determined by 1H-NMR.
MW	816.0
Purity	≥95% (HPLC)
Solubility	Slightly soluble in methanol or DMSO; insoluble in water.
Source	Isolated from Streptomyces griseus.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light when in solution.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

V-ATPase Blockade Reduces Renal Gluconeogenesis and Improves Insulin Secretion in Type 2 Diabetic Rats: J. Hirao, et al.; Hypertens. Res. 43, 1079 (2020), Abstract — Full Text
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer 16, 493 (2016), Abstract — Full Text
Overexpression of caveolin-1 reduces Taxol resistance in human osteosarcoma cells by attenuating PI3K-Akt-JNK dependent autophagy: Guan, J., Yuan, Z., et al.; Exp. Ther. Med. 12, 2815 (2016), Abstract
Autophagy, bafilomycin and cell death: the a-B-cs” of plecomacrolide-induced neuroprotection”””: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Abstract
Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004), Abstract
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997), Abstract
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984), Abstract

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