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ATPase inhibitor
- Potent and selective inhibitor of vacuolar H+ATPases
- Compound used to study autophagy in a variety of cells
- Highly cited
Bafilomycin A1 is a macrolide antibiotic produced by Streptomyces with diverse biological activities. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=0.04-0.4nmol/mg). Bafilomycin A1 is a valuable tool for distinguishing among different types of ATPases. Bafilomycin A1 inhibits endosomal acidification, lysosomal cholesterol trafficking, as well as autophagosome maturation and protein degradation. Bafilomycin A1 also blocks pH regulation in brain cells.
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Product Details
| Alternative Name |
NSC 381866 |
|---|---|
| Appearance |
White powder to colorless film. |
| CAS |
88899-55-2 |
| Couple Target |
ATPase |
| Couple Type |
Inhibitor |
| Formula |
C35H58O9 |
| MW |
622.8 |
| Purity |
≥95% (HPLC, TLC) |
| Solubility |
Soluble in DMSO (5mg/ml), 100% ethanol, or 100% methanol (5mg/ml). |
| Source |
Streptomyces griseus |
| Technical Info / Product Notes |
Typical concentrations for use in cell culture are 50-100nM. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Reduced systemic autophagy by simultaneous loss of ATG4B, ATG4C and ATG4D leads to accelerated aging in mice: Martínez-García, G. G., Suárez, M. F., et al.; bioRxiv , (2025)
- High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia: A. Saffari, et al.; Nat. Commun. 15, 584 (2024), Abstract
- Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models: T. Kataura, et al.; Cell Death Dis. 15, s41419 (2024), Abstract
- Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in charcot-marie-tooth type 2 neuropathies: A. Sisto, et al.; Autophagy , (2024), Abstract
- Endosomes serve as signaling platforms for RIG-I ubiquitination and activation: K.R. Chen, et al.; Sci. Adv. 10, adq0660 (2024), Abstract
- Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells: Kim, M. S., Bhargava, H. K., et al.; ACS Synth. Biol. 13, 2313 (2024), Abstract
- Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production: Kuga, T., Chiba, A., et al.; Front. Immunol. 15, 1320444 (2024), Abstract
- Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease: Toledano-Zaragoza, A., Enríquez-Zarralanga, V., et al.; Cell Death Dis. 15, 771 (2024), Application(s): In Vitro, Abstract
- Lysosomal BK channels facilitate silica-induced inflammation in macrophages: Kendall, R. L., Holian, A., et al.; Inhal. Toxicol. 36, 31 (2024), Abstract
- Noncanonical function of folate through folate receptor 1 during neural tube formation: Balashova, O. A., Panoutsopoulos, A. A., et al.; Nat. Commun. 15, 1642 (2024), Abstract
- Spatial and functional separation of mTORC1 signalling in response to different amino acid sources: Fernandes, S. A., Angelidaki, D. D., et al.; Nat. Cell Biol. 26, 1918 (2024), Abstract
- Synapsin E-domain is essential for α-synuclein function: Stavsky, A., Parra, L. A., et al.; Elife 12, (2024), Abstract
- An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation: L.M. Simpson, et al.; Cell Chem. Biol. 30, 188 (2023), Abstract
- Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents: I. Maestro, et al.; J. Enzyme Inhib. Med. Chem. 38, 2153841 (2023), Abstract
- Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication: S. Krieg, et al.; Cell. Mol. Life Sci. 80, 72 (2023), Abstract
- Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity: B. Kaur, et al.; Cell Commun. Signal. 21, 258 (2023), Abstract
- A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery: Essletzbichler, P., Sedlyarov, V., et al.; Life Sci. Alliance 6, (2023), Abstract
- A purinergic mechanism underlying metformin regulation of hyperglycemia: Senfeld, J., Peng, Q., et al.; iScience 26, 106898 (2023), Abstract
- Analysis of ATG4C function in vivo: Tamargo-Gómez, I., Martínez-García, G. G., et al.; Autophagy 19, 2912 (2023), Abstract
- ATG9 vesicles comprise the seed membrane of mammalian autophagosomes: Olivas, T. J., Wu, Y., et al.; J. Cell Biol. 222, (2023), Abstract
- Cholesterol-dependent molecular mechanisms contribute to cationic amphiphilic drugs’ prevention of silica-induced inflammation: Kendall, R. L., Holian, A., et al.; Eur. J. Cell Biol. 102, 151310 (2023), Abstract
- DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons: Andreska, T., Lüningschrör, P., et al.; Cell Rep. 42, 112575 (2023), Abstract
- High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia: Saffari, A., Brechmann, B., et al.; Research Square , (2023)
- Interactome mapping reveals a role for LRP10 in autophagy and NDFIP1-mediated α-synuclein secretion: Mascaro, A. C., Ferraro, F., et al.; bioRxiv , (2023)
- LRP10 as a novel α-synuclein regulator in Lewy body diseases: Mascaro, A. C., Grochowska, M. M., et al.; bioRxiv , (2023)
- NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy: Kataura, T., Otten, E. G., et al.; EMBO J. 42, e111372 (2023), Abstract
- Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells: An, J., Ouyang, L., et al.; Theranostics 13, 2825 (2023), Abstract
- Non-canonical function of folate/folate receptor 1 during neural tube formation: Balashova, O. A., Panoutsopoulos, A. A., et al.; bioRxiv , (2023)
- Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis: Ishtayeh, H., Galves, M., et al.; Aging Cell 22, e13949 (2023), Abstract
- Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy: Salemkour, Y., Yildiz, D., et al.; J. Am. Soc. Nephrol. 34, 1823 (2023), Abstract
- PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability: Fevga, C., Tesson, C., et al.; Brain 146, 1496 (2023), Abstract
- Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability: Fernandes, S. A., Angelidaki, D., et al.; bioRxiv , (2023)
- Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance: L. Wrobel, et al.; Nat. Commun. 13, 4146 (2022), Abstract
- ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration: K. Soreng, et al.; J. Cell Sci. 135, jcs259138 (2022), Abstract — Full Text
- Autophagy promotes cell survival by maintaining NAD levels: T. Kataura, et al.; Dev. Cell 57, 2584 (2022), Abstract
- Baicalein activates parkin-dependent mitophagy through NDP52 and OPTN: P. Ke, et al.; Cells 11, 1132 (2022), Abstract — Full Text
- Basal autophagy is necessary for a pharmacologic PPARα transactivation: E.Y. Kim, et al.; Cells 11, 754 (2022), Abstract — Full Text
- BNIP3L/NIX regulates both mitophagy and pexophagy: L.P. Wilhelm, et al.; EMBO J. 41, e111115 (2022), Abstract — Full Text
- CFTR modulators restore acidification of autophago-lysosomes and bacterial clearance in cystic fibrosis macrophages: A. Badr, et al.; Front. Cell. Infect. Microbiol. 12, 819554 (2022), Abstract — Full Text
- Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner: D.E. Berardi, et al.; Sci. Adv. 8, eabo2510 (2022), Abstract — Full Text
- NRF2 activation in autophagy defects suppresses a pharmacological transactivation of the nuclear receptor FXR: E.Y. Kim, et al.; Antioxidants 11, 370 (2022), Abstract — Full Text
- Target protein localization and its impact on PROTAC-mediated degradation: L.M. Simpson, et al.; Cell Chem. Biol. 29, 1482 (2022), Abstract
- The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics: M.Y.W. Ng, et al.; Nat. Commun. 13, 6283 (2022), Abstract — Full Text
- Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death: D. Frank, et al.; iScience 25, 104632 (2022), Abstract — Full Text
- V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy: X. Jia, et al.; J. Cell Biol. 221, e202206040 (2022), Abstract — Full Text
- Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy: T. Sønstevold, et al.; Cells 10, 3432 (2021), Abstract
- Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy: T.A. Giovannucci, et al.; Autophagy 5, 1554862 (2021), Abstract
- The SZT2 Interactome Unravels New Functions of the KICSTOR Complex: C. Cattelani, et al.; Cells 10, 2711 (2021), Abstract
- ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells: A.M. Schläfli, et al.; Sci. Rep. 11, 9011 (2021), Abstract — Full Text
- Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models: L.K. Cuddy, et al.; STAR Protoc. 2, 100340 (2021), Abstract — Full Text
- ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration: I. Tamargo-Gomez, et al.; Cell Death Differ. 28, 2651 (2021), Abstract — Full Text
- Ecd promotes U5 snRNP maturation and Prp8 stability: S. Erkelenz, et al.; Nucleic Acids Res. 49, 1688 (2021), Abstract — Full Text
- GAK and PRKCD are positive regulators of PRKN-independent mitophagy: M.J. Munson, et al.; Nat. Commun. 12, 6101 (2021), Abstract — Full Text
- Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo: S. Estfanous, et al.; Sci. Rep. 11, 855 (2021), Abstract — Full Text
- Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response: T. Chen, et al.; Cell Death Differ. 28, 1865 (2021), Abstract — Full Text
- Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner: C. Karabiyik, et al.; Dev. Cell 56, 1961 (2021), Abstract
- Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide: P. Santucci, et al.; Nat. Commun. 12, 3816 (2021), Abstract — Full Text
- Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum: M. Kuijpers, et al.; Neuron 109, 299 (2021), Abstract — Full Text
- Non-canonical glutamate signaling in a genetic model of migraine with aura: P.D. Parker, et al.; Neuron 109, 611 (2021), Abstract
- SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation: D.W. Sanders, et al.; Elife 10, e65962 (2021), Abstract — Full Text
- The ULK1 kinase, a necessary component of the pro-regenerative and anti-aging machinery in Hydra: N. Suknovic, et al.; Mech. Ageing Dev. 194, 111414 (2021), Abstract
- Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson’s Disease: I. Maestro, et al.; ACS Chem. Neurosci. 12, 4512 (2021), Abstract
- Macrophage autophagy protects against hepatocellular carcinogenesis in mice: A. Deust, et al.; Sci. Rep. 11, 18809 (2021), Abstract
- TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells: B. Relic, etr al.; Biochem. J. 478, 3099 (2021), Abstract
- Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology: W. El Manaa, et al.; Autophagy 17, 4363 (2021), Abstract
- GSK3B induces autophagy by phosphorylating ULK1: H.Y. Ryu, et al.; Exp. Mol. Med. 53, 369 (2021), Abstract
- Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization: T. Ziglari, et al.; Int. J. Mol. Sci. 22, 2277 (2021), Abstract — Full Text
- Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons: Z. Hanss, et al.; Mov. Disord. 36, 704 (2021), Application(s): Treatment of iPSCs-derived neurons, Abstract — Full Text
- ABCE1 Regulates RNase L-Induced Autophagy during ViralInfections: B. Ramnan, et al.; Viruses 13, 315 (2021), Abstract — Full Text
- Cyclin-G-associated kinase GAK/Aux orchestrates glial autophagy via Atg9 phosphorylation in Parkinson’s disease: Zhang, S., Wang, L., et al.; bioRxiv , (2021)
- SNARE-dependent mitochondria-lysosome contacts regulate glial mitochondrial dynamics and dopaminergic neuron survival: Wang, H., Wang, L., et al.; bioRxiv , (2021)
- A conserved ATG2‐GABARAP family interaction is critical for phagophore formation: M. Bozic, et al.; EMBO Rep. 21, e48412 (2020), Abstract — Full Text
- A DNM2 centronuclear myopathy mutation reveals a link between recycling endosome scission and autophagy: C. Puri, et al.; Dev. Cell 53, 154 (2020), Abstract
- Antibody RING-mediated destruction of endogenous proteins: A.F.M. Ibrahim, et al.; Mol. Cell 79, 155 (2020), Abstract — Full Text
- Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits: S. Jung, et al.; Autophagy 16, 512 (2020), Abstract — Full Text
- CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis: H. An, et al.; Autophagy 16, 1598 (2020), Abstract — Full Text
- Cordycepin inhibits human gestational choriocarcinoma cell growth by disrupting centrosome homeostasis: C. Wang, et al.; Drug Des. Devel. Ther. 14, 2987 (2020), Abstract — Full Text
- High levels of ROS impair lysosomal acidity and autophagy flux in glucose-deprived fibroblasts by activating ATM and erk pathways: S.B. Song, et al.; Biomolecules 10, 761 (2020), Abstract — Full Text
- Inducible degradation of target proteins through a tractable affinity-directed protein missile system: L.M. Simpson, et al.; Cell Chem. Biol. 27, 1164 (2020), Abstract — Full Text
- Interleukin (IL)-6: a friend or foe of pregnancy and parturition? Evidence from functional studies in fetal membrane cells: C. Omere, et al.; Front. Physiol. 11, 891 (2020), Abstract — Full Text
- MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis: A.L. Samson, et al.; Nat. Commun. 11, 3151 (2020), Abstract — Full Text
- mTORC2 assembly is regulated by USP9X-mediated deubiquitination of RICTOR: L. Wrobel, et al.; Cell Rep. 33, 108564 (2020), Abstract
- Photocrosslinking activity-based probes for ubiquitin RING E3 ligases: S. Mathur, et al.; Cell Chem. Biol. 27, 74 (2020), Abstract — Full Text
- Semi-automated quantitation of mitophagy in cells and tissues: L. Montava-Garriga, et al.; Mech. Ageing Dev. 185, 111196 (2020), Abstract — Full Text
- Stretch, scratch, and stress: Suppressors and supporters of senescence in human fetal membranes: L.S. Richardson, et al.; Placenta 99, 27 (2020), Abstract — Full Text
- Targeted degradation of SLC transporters reveals amenability of multi-pass transmembrane proteins to ligand-induced proteolysis: A. Bensimon, et al.; Cell Chem. Biol. 27, 728 (2020), Abstract — Full Text
- The insufficiency of ATG4A in macroautophagy: N. Nguyen, et al.; J. Biol. Chem. 295, 13584 (2020), Abstract — Full Text
- AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy: M. Dohmen, et al.; Nat. Commun. 11, 1032 (2020), Abstract — Full Text
- Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol. 33, 903 (2020), Abstract
- Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis: D. Santovito, et al.; Sci. Transl. Med. 12, eaaz2294 (2020), Abstract
- K63-linked ubiquitylation induces global sequestration of mitochondria: T.J.C. Richard, et al.; Sci. Rep. 10, 22334 (2020), Abstract — Full Text
- Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes: Joshi, B. S., de Beer, M. A., et al.; ACS Nano 14, 4444 (2020), Abstract
- Intracellular localisation ofi>Mycobacterium tuberculosis/i>affects antibiotic efficacy: Santucci, P., Greenwood, D. J., et al.; bioRxiv , (2020)
- ATG2 transports lipids to promote autophagosome biogenesis: D.P. Valverde, et al.; J. Cell Biol. 218, 1787 (2019), Abstract — Full Text
- Autophagy mediates astrogenesis in adult hippocampal neural stem cells: S. Ha, et al.; Exp. Neurobiol. 28, 229 (2019), Abstract — Full Text
- Bypassing pan-enterovirus host factor PLA2G16: J. Baggen, et al.; Nat. Commun. 10, 3171 (2019), Abstract — Full Text
- Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes: A.H. Lystad, et al.; Nat. Cell Biol. 21, 372 (2019), Abstract — Full Text
- ER-targeted Beclin 1 supports autophagosome biogenesis in the absence of ULK1 and ULK2 kinases: T. Anwar, et al.; Cells 8, 475 (2019), Abstract — Full Text
- Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone: C. Vrahnas, et al.; Nat. Commun. 10, 3436 (2019), Abstract — Full Text
- Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies: M. Haidar, et al.; Autophagy 15, 1051 (2019), Abstract — Full Text
- Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine: R. Burmeister, et al.; Inhal. Toxicol. 31, 274 (2019), Abstract — Full Text
- Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment: A. Dumont, et al.; Cell Death Dis. 10, 485 (2019), Abstract — Full Text
- Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells: R.Willbold, et al.; Cell Death Dis. 10, 601 (2019), Abstract — Full Text
- Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models: M.C. Silva, et al.; Elife 8, e45457 (2019), Abstract — Full Text
- A conserved ATG2-GABARAP interaction is critical for phagophore closure: Bozic, M., van den Bekerom, L., et al.; bioRxiv , (2019)
- Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality: Kulkarni, U., Zemans, R. L., et al.; Mucosal Immunol. 12, 545 (2019), Abstract
- Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death: P. Szalai, et al.; Cell Calcium 76, 48 (2018), Abstract
- A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation: C. Sheng, et al.; Nat Commun. 9, 4047 (2018), Abstract — Full Text
- The IAP family member BRUCE regulates autophagosome-lysosome fusion: P. Ebner, et al.; Nat. Commun. 9, 599 (2018), Abstract — Full Text
- Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis: B. Carroll, et al.; Nat. Commun. 9, 256 (2018), Abstract — Full Text
- Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases: Kauffman, K. J., Yu, S., et al.; Autophagy 14, 992 (2018), Abstract
- LRWD1 Regulates Microtubule Nucleation and Proper Cell Cycle Progression in the Human Testicular Embryonic Carcinoma Cells: Wang, C. Y., Hong, Y. H., et al.; J. Cell. Biochem. 119, 314 (2018), Abstract
- Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function: Iseka, F. M., Goetz, B. T., et al.; J. Immunol. 200, 483 (2018), Abstract
- SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2: Søreng, K., Munson, M. J., et al.; EMBO Rep. 19, (2018), Abstract
- The anti-apoptosis ubiquitin E3 ligase XIAP promotes autophagosome-lysosome fusion during autophagy: Poetsch, I., Ebner, P., et al.; bioRxiv , (2018)
- The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons: Koren, I., Timms, R. T., et al.; Cell 173, 1622 (2018), Abstract
- The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines: Luhr, M., Sætre, F., et al.; Bio Protoc. 8, e2836 (2018), Abstract
- Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo: M. Lehmann, et al.; Eur. Respir. J. 50, 1602367 (2017), Abstract — Full Text
- Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection: Serfass, J. M., Takahashi, Y., et al.; J. Biol. Chem. 292, 10097 (2017), Abstract
- Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis: Julian, L. M., Delaney, S. P., et al.; Cancer Res. 77, 5491 (2017), Abstract
- Illuminating vital surface molecules of symbionts in health and disease: Hudak, J. E., Alvarez, D., et al.; Nat. Microbiol. 2, 17099 (2017), Abstract
- Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes: Agarwal, A., Wu, P. H., et al.; Neuron 93, 587 (2017), Abstract
- SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair: G. Hewitt, et al.; Autophagy 12, 1917 (2016), Abstract — Full Text
- Legionella pneumophilaS1P-lyase targets host sphingolipid metabolism and restrains autophagy: M. Rolando, et al.; PNAS 113, 1901 (2016), Abstract — Full Text
- Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer 16, 493 (2016), Application(s): Transient knock-down of V-ATPase, Abstract — Full Text
- Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS: P. Ziltener, et al.; PLoS One 12, e1005591 (2016), Application(s): Cell culture, Abstract — Full Text
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition: D. Park, et al.; Sci. Rep. 6, 21772 (2016), Application(s): Cell culture, Abstract — Full Text
- A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway: Xue, H., Yuan, G., et al.; Autophagy 12, 1129 (2016), Abstract
- Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase: Lin, M., Liu, H., et al.; Autophagy 12, 2145 (2016), Abstract
- Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase: Neumann, Y., Bruns, S. A., et al.; Autophagy 12, 2069 (2016), Abstract
- The autophagy pathway participates in resistance to tomato yellow leaf curl virus infection in whiteflies: Wang, L. L., Wang, X. R., et al.; Autophagy 12, 1560 (2016), Abstract
- Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types: Belzile, J. P., Sabalza, M., et al.; J. Virol. 90, 1259 (2016), Abstract
- Revealing the fate of cell surface human P-glycoprotein (ABCB1): The Lysosomal Degradation Pathway: K. Katayama, et al.; Biochim. Biophys. Acta 1853, 2361 (2015), Application(s): Cell Culture, Abstract
- The role of cytoplasmic-to-lysosomal pH gradient in hydrophobic weak base drug sequestration in lysosomes: B. Zhitomirsky, et al.; Cancer Cell Microenviron. 2, e807 (2015), Application(s): Cell Culture, Fluorescence Microscopy, Full Text
- Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry: A.M. Schläfli, et al.; Eur. J. Histochem. 59, 137 (2015), Application(s): Cell Culture, Abstract — Full Text
- Pharmacological Inhibition of ULK1 Blocks mTOR-Dependent Autophagy: K. J. Petherick, et al.; J. Biol. Chem. 290, 11376 (2015), Application(s): Cell Culture, Abstract — Full Text
- GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling: C. Stretton, et al.; Biochem. J. 470, 207 (2015), Application(s): Treatment of U2OS human osteosarcoma cell line culture, Abstract — Full Text
- ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells: Burkard, C., Verheije, M. H., et al.; J. Virol. 89, 4434 (2015), Abstract
- Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux: Yang, Y., Zhang, L. H., et al.; J. Cell. Mol. Med. 19, 1055 (2015), Abstract
- Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function: Felzen, V., Hiebel, C., et al.; Cell Death Dis. 6, e1812 (2015), Abstract
- Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists: Cheng, H., Lear-Rooney, C. M., et al.; J. Virol. 89, 9932 (2015), Abstract
- Measuring autophagy in stressed cells: Sharifi, M. N., Mowers, E. E., et al.; Methods Mol. Biol. 1292, 129 (2015), Abstract
- A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system: Schlecht, U., Suresh, S., et al.; BMC Genomics 15, 263 (2014), Abstract
- Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells: Aryal, P., Kim, K., et al.; FEBS J. 281, 4644 (2014), Abstract
- Control of photoreceptor autophagy after retinal detachment: the switch from survival to death: Chinskey, N. D., Zheng, Q. D., et al.; Invest. Ophthalmol. Vis. Sci. 55, 688 (2014), Abstract
- Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner: Burkard, C., Verheije, M. H., et al.; PLoS Pathog. 10, e1004502 (2014), Abstract
- DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells: Yang, Y. M., Park, S., et al.; Korean J. Physiol. Pharmacol. 18, 89 (2014), Abstract
- Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase: Burkard, C., Bloyet, L. M., et al.; PLoS One 9, e101762 (2014), Abstract
- Guanylin peptides regulate electrolyte and fluid transport in the Gulf toadfish (Opsanus beta) posterior intestine: Ruhr, I. M., Bodinier, C., et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R1167 (2014), Abstract
- Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis: Devadas, D., Koithan, T., et al.; J. Virol. 88, 13378 (2014), Abstract
- Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase: Hamacher-Brady, A., Choe, S. C., et al.; Cell Death Differ. 21, 1862 (2014), Abstract
- Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity: Teigler, J. E., Kagan, J. C., et al.; J. Virol. 88, 10354 (2014), Abstract
- The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein: Kirsch, S., Schrezenmeier, E., et al.; Int. J. Mol. Med. 33, 795 (2014), Abstract
- Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation: D. Brigger, et al.; Biochem. Biophys. Res. Commun. 438, 283 (2013), Application(s): Fluorescence Microscopy, PCR, WB, Abstract
- Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation: Betin, V. M., Singleton, B. K., et al.; Autophagy 9, 881 (2013), Abstract
- Determinants of pH-dependent modulation of translocation in dermonecrotic G-protein-deamidating toxins: Repella, T. L., Ho, M., et al.; Toxins (Basel) 5, 1167 (2013), Abstract
- Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses: Zaade, D., Schmitz, J., et al.; PLoS One 8, e57674 (2013), Abstract
- Modulation of intracellular calcium homeostasis blocks autophagosome formation: Engedal, N., Torgersen, M. L., et al.; Autophagy 9, 1475 (2013), Abstract
- The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling: S.M. Bernhard, et al.; Biochem. Pharmacol. 84, 1643 (2012), Application(s): WB, Cell Lysis, Abstract
- Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection: Chen, C. C., Tsai, S. H., et al.; PLoS One 7, e36292 (2012), Abstract
- Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells: Bolt, A. M., Zhao, F., et al.; Toxicol. Appl. Pharmacol. 264, 255 (2012), Abstract
- Internalized gap junctions are degraded by autophagy: Fong, J. T., Kells, R. M., et al.; Autophagy 8, 794 (2012), Abstract
- Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB: Paul, S., Kashyap, A. K., et al.; Immunity 36, 947 (2012), Abstract
- Arf6-dependent intracellular trafficking of Pasteurella multocida toxin and pH-dependent translocation from late endosomes: Repella, T. L., Ho, M., et al.; Toxins (Basel) 3, 218 (2011), Abstract
- Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis: Besirli, C. G., Chinskey, N. D., et al.; Invest. Ophthalmol. Vis. Sci. 52, 4193 (2011), Abstract
- Beclin 1-independent autophagy contributes to apoptosis in cortical neurons: Grishchuk, Y., Ginet, V., et al.; Autophagy 7, 1115 (2011), Abstract
- Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines: Bolt, A. M., Byrd, R. M., et al.; Toxicol. Appl. Pharmacol. 244, 366 (2010), Abstract
- Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells: Koarai, A., Sugiura, H., et al.; Am. J. Respir. Cell Mol. Biol. 42, 651 (2010), Abstract
- Autophagy, bafilomycin and cell death: the a-B-cs” of plecomacrolide-induced neuroprotection”””: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Review, Abstract
- Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006), Abstract
- Reduced capacitative calcium entry correlates with vesicle accumulation and apoptosis: S. Jaydev, et al.; J. Biol. Chem. 274, 8261 (1999), Abstract
- Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Dröse & K. Altendorf; J. Exp. Biol. 200, 1 (1997), Abstract
- Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts: A.J. Saurin, et al.; Biochem. J. 313, 65 (1996), Abstract
- Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995), Abstract
- Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995), Abstract — Full Text
- The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein: C. Haass, et al.; J. Biol. Chem. 270, 6186 (1995), Abstract — Full Text
- Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans: C.M. Calvert & D. Sanders; J. Biol. Chem. 270, 7272 (1995), Abstract — Full Text
- Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells: H. Palokangas, et al.; J. Biol. Chem. 269, 17577 (1994), Abstract — Full Text
- Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps: B.P. Crider, et al.; J. Biol. Chem. 269, 17379 (1994), Abstract — Full Text
- A depolarization-stimulated, bafilomycin-inhibitable H+ pump in hippocampal astrocytes: C.A. Pappas & B.R. Ransom; Glia 9, 280 (1993), Abstract
- Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993), Abstract — Full Text
- Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993), Abstract
- Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991), Abstract
- Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991), Abstract — Full Text
- Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990), Abstract
- Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990), Abstract
- The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase: T. Umata, et al.; J. Biol. Chem. 265, 21940 (1990), Abstract — Full Text
- The evolution of H+-ATPases [see comments]: N. Nelson & L. Taiz; TIPS 14, 113 (1989), (Review), Abstract
- Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988), Abstract
- Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984), Abstract
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