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BAFF monoclonal antibody (Buffy-2)

ALX-804-131

19 citations

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This antibody is covered by our Worry-Free Guarantee.

BAFF monoclonal antibody (Buffy-2) Immunohistochemistry — **Figure:** Staining of paraffin section of synovial tissue from a patient with Rheumatoid Arthritis. Arrows indicate vessels (20x) staining positive for BAFF using Buffy-2.
**Method:** Tissues are in paraffin sections. Sections are de-waxed and rehydrated, then cooked. Sections are stained in wet boxes, rehydrated and finally prepared as coverslip slides using Eukitt solution.

BAFF monoclonal antibody (Buffy-2) Schematic structure of immunogen — *Schematic structure of rhsBAFF (aa. 83-285). MAb to BAFF (Buffy-2) recognizes the TNF-homology domain.*

Product Details

Alternative Name	B cell-activating factor, BLyS, TALL-1, THANK, zTNF4, TNFSF 13B/20, CD257
Application	Flow Cytometry, IHC (FS), IHC (PS), WB
Clone	Buffy-2
Crossreactivity	Weakly cross-reacts with mouse BAFF.
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant human soluble BAFF (aa 83-285) (Prod. No. ALX-522-025).
Isotype	IgM
Purity Detail	Purified by IgM purification HP column.
Source	Purified from ascites.
Species Reactivity	Human
Specificity	Recognizes membrane-bound and soluble BAFF.
UniProt ID	Q9Y275
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored as recommended.
Handling	Avoid freeze/thaw cycles.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren’s syndrome: results of the BELISS study: Seror, R., Nocturne, G., et al.; Arthritis Res. Ther. 17, 241 (2015), Abstract
The Characteristics and Significance of Locally Infiltrating B Cells in Lupus Nephritis and Their Association with Local BAFF Expression.: Shen, Y., Li, T., et al.; Int. J. Rheumatol. 2013, 954292 (2013), Application(s): IHC / Reactant(s): Human, Abstract
Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjögren’s syndrome: Roescher, N., Lodde, B. M., et al.; Oral Dis. 18, 96 (2012), Abstract
APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells: G. Notas, et al.; J. Immunol. 189, 4748 (2012), Application(s): IHC, Abstract
BAFF levels are increased in lesional skin and sera in patients with cutaneous T-cell lymphoma: Ohmatsu, H., Sugaya, M., et al.; Br. J. Dermatol. 167, 359 (2012), Abstract
Detection of the TNFSF members BAFF, APRIL, TWEAK and their receptors in normal kidney and renal cell carcinomas: V. Pelekanou, et al.; Anal. Cell. Pathol. (Amst.) 34, 49 (2011), Application(s): IHC / Reactant(s) Human, Abstract
p52 Activation in monomorphic B-cell posttransplant lymphoproliferative disorder/diffuse large B-cell lymphoma without BAFF-R expression.: Lazure, T., Rince, P., et al.; Am. J. Pathol. 179, 1630 (2011), Application(s): IHC / Reactant(s): Human, Abstract
Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus: V.T. Chu, et al.; Arthritis Rheum. 60, 2083 (2009), Application(s): Flow Cytometry, Abstract
Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development: V.I. Alexaki, et al.; J. Immunol. 183, 5948 (2009), Application(s): IHC / Reactant(s) Human, Abstract
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts: C. Bossen, et al.; Blood 111, 1004 (2008), Application(s): Western Blot , Abstract

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BAFF (soluble) (human), (recombinant)

ALX-522-025

18 citations

Alternative Name	THANK, zTNF4, TALL-1, BlyS, TNFSF 13B/20, CD257
Purity	≥95% (SDS-PAGE)
Source	Produced in E. coli. The extracellular domain of human BAFF (aa 83-285) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG^®-tag.

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BAFF monoclonal antibody (Buffy-2)

ALX-804-131

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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