BADGE

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PPARγ inhibitor

Antagonist of PPARγ. Binds to PPARγ with an apparent K_d of 100µM.

Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.

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Alternative Name	Bisphenol A diglycidyl ether, 2,2′-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
Appearance	Colorless viscous liquid.
CAS	1675-54-3
Couple Target	PPAR
Couple Type	Inhibitor
Formula	C₂₁H₂₄O₄
Identity	Determined by IR.
MW	340.4
MeltingPoint	40-44°C
Purity	≥85%
Solubility	Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide; insoluble in PBS, pH 7.2.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring: Yee, J. K., Lee, W. N., et al.; Nutr. Metab. (Lond.) 9, 62 (2012), Abstract
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002), Abstract — Full Text
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002), Abstract
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002), Abstract
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000), Abstract — Full Text

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