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CD276 was initially identified as a member of the B7 family of proteins. CD276 mRNA is widely expressed, but its protein expression is usually rather low. CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response. CD276 also plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity. It is a possible therapeutic target for at least a subset of cancers.
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Flow cytometry analysis of B7-H3 in HEK293 cells using B7-H3 antibody at 1 µg/ml. Blue: untransfected HEK293 cells. Yellow: B7-H3 over expressing HEK293 cells.
Western blot analysis of B7-H3 in HEK293 cells using B7-H3 antibody at (A) 0.25 (B) 0.5 and (C) 1 µg/ml.
Immunohistochemistry of B7-H3 in human colon carcinoma tissue using B7-H3 Antibody and control mouse IgG (corner box) at 2 µg/ml.
Immunofluorescence of B7-H3 in HEK293 cells using B7-H3 Antibody at 5 µg/ml. Green: B7-H3 Antibody [2A7] Blue: DAPI staining
Immunocytochemistry of B7-H3 in HEK293 cells using B7-H3 antibody and control mouse IgG antibody (left corner box) at 1 µg/ml.
| Regulatory Status |
RUO – Research Use Only |
|---|
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| Alternative Name | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
|---|---|
| Application | Flow Cytometry, IP, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
|---|---|
| Application | IHC (PS) |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
|---|---|
| Application | ELISA, IP, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | A-Proliferation-inducing ligand, TNFSF 13, CD256 |
|---|---|
| Application | ELISA, IP, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |