B581

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Farnesyltransferase inhibitor

A potent and selective, cell-permeable farnesyl transferase inhibitor IC₅₀=21 nM, 30-fold selective over geranylgeranyl transferase.

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Appearance	White to off-white powder.
CAS	149759-96-6
Couple Target	Farnesyltransferase
Couple Type	Inhibitor
Formula	C₂₂H₃₈N₄O₃S₂
Identity	Determined by ESI-MS.
MW	470.7
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (5mg/ml) or water (2mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells: M. El Gaafary, et al.; Biomed. Pharmacother. 156, 113873 (2022), Application(s): Ftase inhibition in activity assay, Abstract
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation: A. D. Cox, et al.; J. Biol. Chem. 269, 19203 (1994), Abstract — Full Text
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: M. A. Garcia, et al.; J. Biol. Chem. 268, 18415 (1993), Abstract — Full Text

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